Deferasirox desensitization

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Deferasirox induced liver injury in haemochromatosis.

Durg-induced liver injury is a common side-effect of many medicines. It is particularly problem when the original condition under treatment is already causing liver damage. This report describes the hepatotoxicity induced by Deferasirox in a patient with haemochromatosis with a discussion of possible pathogenetic mechanism.

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References 1 Li C, Kuti JL, Nightingale CH et al. Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection. J Antimicrob Chemother 2005; 56: 388–95. 2 Roberts JA, Norris R, Paterson DL et al. Therapeutic drug monitoring of antimicrobials. Br J Clin Pharmacol 2011; doi: 10.1111/ j.1365-2125.2011.04080.x. 3 Seyler S, Cotton...

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Pharmacokinetics and Safety of Deferasirox in Subjects with Chronic Kidney Disease Undergoing Haemodialysis Running title: Deferasirox in chronic kidney disease

Aim: Treatment of chronic kidney disease (CKD) includes parenteral iron therapy, and these infusions can lead to iron overload. Secondary iron overload is typically treated with iron chelators, of which deferasirox is one of the most promising. However, it has not been studied in patients with CKD and iron overload. Methods: A pilot study was conducted to evaluate the pharmacokinetics and safet...

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ژورنال

عنوان ژورنال: The Journal of Allergy and Clinical Immunology: In Practice

سال: 2016

ISSN: 2213-2198

DOI: 10.1016/j.jaip.2015.09.007